发给老马备查:
, r P6 H" L' k8 L滴水察海(69304838) 15:23:23
! W# G( | z4 l6 b Y- T老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
9 C0 K7 B m4 D5 T' p: G吉非替尼和S-1连用的依据9 S7 o* S, O1 N
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
" w& A/ ]; A( k5 _7 P6 Y- c是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达* w- x- g8 S6 _; R: q
这样是不是推理出,耐药后,可以用S-1和培美了?
9 P; M/ ]# i2 O; ]; h7 s# L结论:) f5 j) S3 t" s* ~3 Q; W" v. M
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |