发给老马备查:
5 o4 n% Y9 \! k9 J" A! z滴水察海(69304838) 15:23:23
4 s U2 |$ M6 D* ?, m老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱) m- O) p$ W) W& t
吉非替尼和S-1连用的依据; {& F* V' o. S$ c5 Q }' O6 M' k
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
, L& V2 w! N! r9 T0 }8 W3 Y2 d) c是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达+ e: Z4 f9 t$ z5 q; k
这样是不是推理出,耐药后,可以用S-1和培美了?
$ _5 j- U2 O1 A5 h- `) d结论:
) S9 i w0 x4 C3 z如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |