发给老马备查:
# Z) [( A8 o) E滴水察海(69304838) 15:23:23
) b" J5 B6 G5 Z5 v- k老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
2 A7 `' ?3 H& S4 }0 P吉非替尼和S-1连用的依据
) S, i% h3 R e' y, D7 rGefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro., O6 Y" U6 h( f/ ]4 U) B
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
9 O( c) U1 H' h! n, a这样是不是推理出,耐药后,可以用S-1和培美了?
7 t+ S' h3 {$ |% c结论:5 D7 o7 o4 I# I
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |