看见一个 Expert Review of Anticancer Therapy。你们前面用依维莫斯,血、肝肾功能还好。下一步是否考虑索拉非尼+依维莫斯。供你参考。2 N _! M% O$ E5 a
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Currently available feasibility data for possible combination strategies. 1 l C6 p$ i) `: v$ T: w
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Combination Feasibility according to preliminary data 4 [% ~: h) m$ s9 y, W; G! P
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Bevacizumab + sorafenib Yes, reduced dose
! b: t2 j8 J& m9 c+ G" ]8 aBevacizumab + sunitinib† No + E3 |8 ]5 A$ Q# \( V
Bevacizumab + temsirolimus Yes
0 v! L$ m# t4 q* L1 Y) k1 @Bevacizumab + everolimus Yes
- Q7 X! `1 n1 FSorafenib + sunitinib ? ' [) {: V( n' O3 o1 o, ~ E
Sorafenib + temsirolimus Yes, reduced dose
1 u" k$ D% C/ X3 k) j/ {Sorafenib + everolimus Yes, reduced dose
. D4 ]- p: y: i: v6 f4 SSunitinib + temsirolimus† No
7 a- i1 l- A6 ^/ l! c3 e& ^Sunitinib + everolimus ? ) P" P3 u& j8 }
Temsirolimus + everolimus ? 1 M3 N+ |, m2 z5 U9 \" ]
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, K; q% h2 r1 \" R3 `2 V) W- ]†Led to US FDA warning.: O; S* L4 e. p3 D( ], o, @: |; X3 l
?: As yet unattempted combination.
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